BRD4 represses developmental and neuronal genes through interaction with PRC1.6
Fanny Boulet, Manthan Patel, Zeinab Shadman Zanjani, Nuria Andrés-Sánchez, Anam Ijaz, Debosree Pal, Pankaj Dubey, Aoife Murray, Dean Nižetić, Michael D. LeClaire, Karina L. Bursch, Brian C. Smith, Pradeepa M. Madapura
Acute BRD4 degradation and BD2 mutations de-repress bivalent developmental and neuronal genes in human stem cells and organoids, consistent with BRD4 recruitment by H3K14ac/H3K23ac and interaction with PRC1.6.
bioRxiv · Aug 5, 2026 · PreprintMolecular Biology✦ In-depth digest