Manthan Patel

Acute BRD4 degradation and BD2 mutations de-repress bivalent developmental and neuronal genes in human stem cells and organoids, consistent with BRD4 recruitment by H3K14ac/H3K23ac and interaction with PRC1.6.

The paper identifies non-canonical enhancers in human pluripotent stem cells that lack typical enhancer features but regulate gene expression and cell fate.

This study identifies a transposable element (TE) signature in maternal cell-free RNA that predicts preeclampsia with high accuracy.

The paper introduces a new antibody capture method to accurately capture G4 structures in human cells and shows that G4 formation is constrained by sequence properties and nuclear environment.

This study shows PSIP1 reduces R-loops at transcription sites, preventing DNA damage and maintaining genome integrity in human and mouse cells.

The paper shows H4K16ac activates LINE1 and LTR transcription, contributing to cis-regulatory function by maintaining active chromatin at TEs.

The paper investigates chromosomal chimeras in human cell cultures, showing their occurrence at genomic repeats and regulation by stress and CGGBP1 depletion.

The paper shows CGGBP1-dependent CTCF-binding sites inhibit ectopic transcription from the SV40 promoter by acting as transcription barriers.

The paper shows that CGGBP1 regulates cytosine methylation at CTCF-binding sites deterministically, influencing CTCF occupancy and function.

This study shows CGGBP1 regulates CTCF occupancy at repeats and their chromatin barrier function through ChIP-sequencing and histone modification analysis.