Debosree Pal

BRD4 represses developmental and neuronal genes through interaction with PRC1.6

Acute BRD4 degradation and BD2 mutations de-repress bivalent developmental and neuronal genes in human stem cells and organoids, consistent with BRD4 recruitment by H3K14ac/H3K23ac and interaction with PRC1.6.

Non-coding mutations at enhancer clusters contribute to pancreatic ductal adenocarcinoma

The paper identifies non-coding mutations in enhancer clusters associated with pancreatic ductal adenocarcinoma and validates their functional impact using computational and experimental methods.

H4K16ac activates transcription of transposable elements and contribute to their cis regulatory function

The paper shows H4K16ac activates LINE1 and LTR transcription, contributing to cis-regulatory function by maintaining active chromatin at TEs.

Identification of PAX6 and NFAT4 as the transcriptional regulators of lncRNA Mrhl in neuronal progenitors

The paper identifies PAX6 and NFAT4 as transcriptional regulators of lncRNA Mrhl in neuronal progenitors, showing their direct binding and interaction in regulating Mrhl expression.

LncRNA Mrhl orchestrates differentiation programs in mouse embryonic stem cells through chromatin mediated regulation

This study identifies lncRNA Mrhl as a chromatin-bound regulator that influences differentiation programs in mouse embryonic stem cells by modulating chromatin architecture.