Hierarchical Coordination of Polymerase Theta and RAD51 Resolves Clustered Replication Fork Collapse
Chelsea M. Smith, Dennis A. Simpson, Paolo Guerra, Wanjuan Feng, Simon W. Ellington, Dongbo Lu, Carel Fijen, Natalie M. Boylston, Kishore Kumar CHIRUVELLA, Iman El‐Shiekh, Rachel Elizabeth Lee, Anne‐Sophie Wozny, Andrew Marcel Pregnall, Brian E. Eckenroth, Afaf Helmy El-Sagheer, , Gaorav P. Gupta
The paper shows Pol{theta} is recruited via RAD51 ubiquitylation to resolve clustered ICLs causing replication fork collapse in HR-proficient cells.
bioRxiv · Jul 2, 2025 · PreprintCell Biology