Gaorav P. Gupta

StarTrail identifies rapidly changing regions and cliff genes in spatial omics data, improving boundary detection and uncovering missed biological insights.

This study identifies Polθ as a therapeutic target in DNMT3A-mutated leukemia by showing its essential role in DNA repair and replication fork restart, and demonstrates that its inhibition enhances standard therapies.

The paper shows Pol{theta} is recruited via RAD51 ubiquitylation to resolve clustered ICLs causing replication fork collapse in HR-proficient cells.

The paper uses single RNA molecule resolution imaging to analyze immunotherapy response in triple negative breast tumors with tertiary lymphoid structures, identifying two tumor types based on immune infiltration and their differential responses to pembrolizumab and radiation therapy.

POLARIS infers cell composition from histology images and identifies layer-specific differentially expressed genes in spatial transcriptomics data.

This paper compares eight ST deconvolution methods using four real datasets to evaluate their performance in inferring cell type composition from spatial transcriptomics data.

This study elucidates how DNA Polymerase Theta identifies microhomologies during repair and shows how this process leads to genomic scars in cancer.

The paper quantifies cell cycle phase durations in human cells and finds they are memoryless and uncoupled, with a mathematical model explaining their independence and potential coupling under dysfunction.