Author

Kishore Kumar CHIRUVELLA

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dale A. RamsdeniD· 2 shared Adam R. KarpfiD· 1 shared Afaf Helmy El-SagheeriD· 1 shared Andrew Marcel PregnalliD· 1 shared Anne‐Sophie WoznyiD· 1 shared Brian E. EckenrothiD· 1 shared Carel FijeniD· 1 shared Carley M. ConoveriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Dale A. RamsdenORCID

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2 papers

Recent·Most cited

A RHNO1-ATR/Chk1 positive feedback loop sustains the DNA replication stress response

Niphat Jirapongwattana, Carley M. Conover, Catalina Trujillo Jaramillo, Kishore Kumar CHIRUVELLA, Joonyoung Her, Gargi Ghosal, Samuel F. Bunting, Dale A. Ramsden, Adam R. Karpf

This study identifies a RHNO1-ATR/Chk1 positive feedback loop that sustains DNA replication stress response and highlights RHNO1 as a therapeutic target in cancer.

bioRxiv · Jul 8, 2026 · PreprintCancer Biology

Hierarchical Coordination of Polymerase Theta and RAD51 Resolves Clustered Replication Fork Collapse

Chelsea M. Smith, Dennis A. Simpson, Paolo Guerra, Wanjuan Feng, Simon W. Ellington, Dongbo Lu, Carel Fijen, Natalie M. Boylston, Kishore Kumar CHIRUVELLA, Iman El‐Shiekh, Rachel Elizabeth Lee, Anne‐Sophie Wozny, Andrew Marcel Pregnall, Brian E. Eckenroth, Afaf Helmy El-Sagheer, , Gaorav P. Gupta

The paper shows Pol{theta} is recruited via RAD51 ubiquitylation to resolve clustered ICLs causing replication fork collapse in HR-proficient cells.

bioRxiv · Jul 2, 2025 · PreprintCell Biology