Paranthaman Senthamarai Kannan

This study identifies Nkx2-1-driven chromatin topology changes in alveolar epithelial progenitor cells that regulate lung regeneration and differentiation.

The paper uses transcriptomic data from amniotic fluid and fetal tissues to identify biomarkers of fetal maturity in rhesus macaques, showing that cell-free RNA can predict lung compliance and gestational age.

This study uses single-nucleus RNA-seq to show that chorioamnionitis disrupts cerebellar cell maturation in preterm nonhuman primates, leading to Purkinje cell loss and altered granule and oligodendrocyte development.

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.