Claire Anne Chougnet

Anakinra reduced preterm labor and inflammation in a Rhesus macaque model of E. coli-induced intrauterine infection.

This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.

The paper uses transcriptomic data from amniotic fluid and fetal tissues to identify biomarkers of fetal maturity in rhesus macaques, showing that cell-free RNA can predict lung compliance and gestational age.

This study uses single-nucleus RNA-seq to show that chorioamnionitis disrupts cerebellar cell maturation in preterm nonhuman primates, leading to Purkinje cell loss and altered granule and oligodendrocyte development.

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.