PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
Hua He, Sheila M. Bell, Ashley Kuenzi Davis…·Jeffrey A. Whitsett
This study shows PRDM3 and PRDM16 regulate chromatin accessibility to support NKX2-1-driven alveolar epithelial differentiation and function, with loss leading to respiratory failure and lineage infidelity.