Author

Paresh Kumar Purohit

University of Notre Dame

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Adrian ChaoiD· 1 shared Éva SzegezdiiD· 1 shared Guoqiang LiuiD· 1 shared Jianping HeiD· 1 shared Jiling WeniD· 1 shared Junling Zhao· 1 shared Loan DuongiD· 1 shared Minzhi LiangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adrian ChaoORCID

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1 paper

Recent·Most cited

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma

Xuechun Wang, Yujing Qin, Loan Duong, Minzhi Liang, Adrian Chao, Rossella Parrotta, Yaoyin Li, Paresh Kumar Purohit, Yihao Fang, Guoqiang Liu, Jianping He, Jiling Wen, Yan Liu, Yuting Zhang, Junling Zhao, , Éva Szegezdi

This study identifies TRAIL as a synthetic essentiality in VHL-deficient ccRCC, showing its regulation by HIF2 and its role in cell proliferation through the p38 MAPK pathway, suggesting a combination therapy strategy.

Proceedings of the National Academy of Sciences · Jul 1, 2026Peer-reviewedCancer Biology