LMNA Haploinsufficiency in Human iPSC-Derived Cardiac Organoids Reveals Early Fibrotic Signaling as a Therapeutically Targetable Process
A. Zuniga, Raúl A Dulce, Karina Dutra Asensi, Arnab Chakraborty, Brooke A. DeRosa, Parker Levitan, Sebastian Borges, Renata L. Volonterio, Monica Huerta Lopez, James Jarad Dollar, Gulum Yenisehirli, Sara Rodríguez, Benjamin I. Schachner, Derek Michael Dykxhoorn, Joshua M. Hare, Stefan Kurtenbach
This study uses cardiac organoids derived from patient iPSCs to show that LMNA haploinsufficiency causes early fibrotic signaling, which can be targeted by antifibrotic drugs.
bioRxiv · Oct 22, 2026 · PreprintCell Biology