Dopaminergic Neurodegeneration Induced by Parkinson's Disease-Linked G2019S LRRK2 is Dependent on Kinase and GTPase Activity
An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan D. Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barnéoud, Darren J. Moore
This study develops a rat model of Parkinson's disease caused by the G2019S LRRK2 mutation and shows that kinase and GTPase activities are critical for neurodegeneration.
Proceedings of the National Academy of Sciences · Jul 6, 2020Peer-reviewedNeuroscience