Behavioral deficits, learning impairment, and enhanced hippocampal excitability in co-isogenic PrnpZH3/ZH3 mice
Andreu Matamoros‐Angles, Arnau Hervera, Jordi Soriano, Eulàlia Martı́, Patricia Carulla, Franc Llorens, Mario Nuvolone, Adriano Aguzzi, Isidró Ferrer, Agnès Gruart, J. M. Delgado-García, José Antonio del Rı́o
This study investigates the role of PrPC in hippocampal function using PrnpZH3/ZH3 mice, finding behavioral deficits, learning impairment, and increased excitability without enhanced LTP.
bioRxiv · Feb 20, 2021 · PreprintNeuroscience