Isidró Ferrer

This study examines the expression and function of taste receptors in glioblastoma, finding that multiple TAS2Rs and TAS1R subunits are active in tumor cells and may influence cancer microenvironment interactions.

This study compares Tau oligomer properties in slowly and rapidly progressive Alzheimer's disease, finding distinct biochemical and proteomic profiles associated with different clinical progression rates.

This study identifies sex-dependent and progressive proteomic changes in the amygdala across Alzheimer's disease stages, revealing potential sex-specific biomarkers and therapeutic targets.

This study characterizes stress granule structural and molecular changes in Alzheimer's disease subtypes using multi-omics approaches, revealing distinct features in rapidly progressive AD.

The paper reports cryo-EM structures of tau filaments from individuals with P301L and P301T MAPT mutations, revealing distinct filament folds associated with FTDP-17.

The paper examines s-KL/m-KL transcript ratio and protein localization in the CNS and their association with AD progression across species.

This paper demonstrates that non-enzymatic methods can isolate brain-derived extracellular vesicles without compromising protein integrity, achieving high yield and purity.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

The paper identifies miR-519a-3p as a potential biomarker for preclinical stages of Alzheimer's disease by showing its early upregulation in AD cerebral samples.

The paper shows that tocilizumab, an IL-6 receptor inhibitor, prevents astrocyte-induced neurotoxicity in Parkinson's disease by blocking IL-6 signaling in neurons.

This study identifies a functional interaction between TDP-43 and USP10, showing USP10 modulates alternative splicing and can reduce TDP-43 toxicity in a mouse model of ALS and FTD.

This study investigates the role of cellular prion protein in tau seeding and spreading using Prnp mutant mice and P301S tauopathy models, finding it significant in the latter but not in Alzheimer's sarkosyl-derived samples.

The paper analyzes lipidomic changes in cerebral cortex and white matter of Alzheimer's disease patients, finding distinct lipid profiles associated with disease progression.

This study investigates how mechanical and chemical cues influence the migration of Cajal-Retzius cells in the developing neocortex, showing that mechanical properties and route stiffness affect their distribution.

The paper identifies transcriptional signatures of synaptic vesicle genes associated with neurodegeneration in Myotonic Dystrophy Type I using transcriptome and brain imaging data.

This study investigates the role of PrPC in hippocampal function using PrnpZH3/ZH3 mice, finding behavioral deficits, learning impairment, and increased excitability without enhanced LTP.

The paper identifies altered calcium-binding proteins in the cerebellum of schizophrenia patients, linking them to synaptic dysfunction and suicide behaviors.

This study identifies a differential lipidomic signature in nuclei of ALS patients, linking lipid changes to disease mechanisms.