SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment
Guadalupe Pereyra, María Inés Mateo, Pablo Miaja…·Paola Bovolenta
This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.