Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis
George Rosenberger, Wenxue Li, Mikko M. Turunen, Jing He, Prem S. Subramaniam, Sergey Pampou, Aaron Timothy Griffin, Charles Karan, Patrick Kerwin, Diana Murray, Barry H. Honig, Yansheng Liu, Andrea Califano
The paper uses phosphoproteomic time-series data and the VESPA algorithm to analyze drug resistance mechanisms in colon cancer cells, revealing adaptive signaling rewiring confirmed by CRISPRko assays.
bioRxiv · Feb 15, 2023 · PreprintSystems Biology