mTORC2 stabilizes HIF-1β to coordinate metabolic adaptation in lung cancer
Morgane Paque, Ning An, Marine Leclercq, Anisa Aliju, Elodie Renaude, Domien Vanneste, Denis Heusdens, Jair Marques, Chinmayi Pednekar, Tillmann Bedau, Juan Fernández-García, Fabienne Perin, Raphael Vanleyssem, Christian Seca, Kim Eiden, , Arnaud Blomme
This study identifies mTORC2 as a convergent dependency in lung cancer that stabilizes HIF-1β to drive metabolic adaptation and tumor progression, revealing a therapeutic target in sphingolipid metabolism.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology