Ritu Raj

Active Nucleosome Sliding, Eviction, and Reassembly Dynamics Can Regulate Chromatin Condensate Organization

This study introduces a model showing that active nucleosome remodeling influences chromatin condensate structure and dynamics by driving swelling, mixing, and segregation.

Interplay of Structural Heterogeneity and Active Remodeling Controls Chromatin Condensate Organization and Dynamics

This study develops coarse-grained models to show how nucleosome spacing and ATP-dependent remodeling influence chromatin condensate structure, dynamics, and organization.

U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP Biogenesis

This study identifies U1C as a key regulator of the SMN complex in snRNP biogenesis, showing that U1C mutations disrupt Sm core assembly and inhibit snRNP formation in cancer.

GPC3-Unc5D complex structure and role in cell migration

This study determines the structure of the GPC3-Unc5D complex and shows its role in guiding neuronal and cancer cell migration.