Mitochondrial cytochrome c accumulation accompanies reduced electron flux through complex IV without enhancing cell sensitivity to apoptosis
Alexander V. Zhdanov, Nadezda A. Brazhe, Evelina I. Nikelshparg, Luke Power, Philip Lewis, Paula V. Silva, Marcel van de Wouw, Patrick B. F. O’Connor, John F. Cryan, Olga V. Sosnovtseva, Dmitry E. Andreev, Martina M. Yordanova, Pavel V. Baranov, Ruslan I. Dmitriev, Dmitri B. Papkovsky
The paper shows that reduced electron flux through complex IV leads to cytochrome c accumulation via increased stability and membrane retention, without increasing apoptosis sensitivity.
bioRxiv · Jun 27, 2026 · PreprintCell Biology