This study evaluates electrically enhanced intraperitoneal drug delivery using nanoparticles and fluorescence lifetime imaging microscopy to track drug penetration and intracellular release.

bioRxiv · Oct 30, 2026 · PreprintPharmacology & Toxicology

Mitochondrial cytochrome c accumulation accompanies reduced electron flux through complex IV without enhancing cell sensitivity to apoptosis

Alexander V. Zhdanov, Nadezda A. Brazhe, Evelina I. Nikelshparg, Luke Power, Philip Lewis, Paula V. Silva, Marcel van de Wouw, Patrick B. F. O’Connor, John F. Cryan, Olga V. Sosnovtseva, Dmitry E. Andreev, Martina M. Yordanova, Pavel V. Baranov, Ruslan I. Dmitriev, Dmitri B. Papkovsky

The paper shows that reduced electron flux through complex IV leads to cytochrome c accumulation via increased stability and membrane retention, without increasing apoptosis sensitivity.

bioRxiv · Jun 27, 2026 · PreprintCell Biology

Fluorescence Lifetime Imaging Microscopy (FLIM) visualizes internalization and biological impact of nanoplastics in live intestinal organoids

Irina A. Okkelman, Hang Zhou, Sergey M. Borisov, Angela C. Debruyne, Austin E.Y.T. Lefebvre, Marcelo Zoccoler, Linglong Chen, Bert Devriendt, Ruslan I. Dmitriev

This paper uses FLIM to study nanoplastic interactions and effects in intestinal organoids, finding species-specific uptake and disruptions in mitochondrial function and inflammation.

Light Science & Applications · Aug 12, 2025Peer-reviewedPharmacology & Toxicology