Ogg1 regulates context-dependent glial states in Alzheimer's disease
Andreas Abentung, Teri Sakshaug, Paulina Schnur, Milena Egiazarian, Catarina Damião, Karoline Aakre, Tobias Obermann, Mirta Sousa, Nicolas Kunath, Magnar Bjørås, Katja Scheffler
This study shows Ogg1 has opposing effects on glial states in Alzheimer's disease, improving memory and reducing amyloid burden in a mouse model while impairing memory under physiological conditions.
bioRxiv · Nov 9, 2026 · PreprintNeuroscience