Prdm16 amplifies Notch signaling and suppresses venous lineage specification to prevent arteriovenous malformations during vascular development
Jore Van Wauwe, Pavithra Janarthanan, Sander Craps, Ashmita KC, Lisabel Asuncion, Pieter Vrancaert, Hannelore Kemps, Margo Daems, Chris Finck, Shane H. Wright, Christian Müller, Nicholas D. Leigh, Thomas Renné, Roxana Ola, Daniela Panáková, , Manu Beerens
This study shows Prdm16 enhances Notch signaling in arterial endothelial cells and suppresses venous fate to prevent arteriovenous malformations in zebrafish and human cells.
Arteriosclerosis Thrombosis and Vascular Biology · Feb 19, 2026Peer-reviewedDevelopmental Biology