Thomas Renné

This study shows Prdm16 enhances Notch signaling in arterial endothelial cells and suppresses venous fate to prevent arteriovenous malformations in zebrafish and human cells.

This study identifies impaired macrophage DNase secretion due to ER stress as a mechanism leading to NET persistence and defective efferocytosis in atherosclerosis.

This study shows that sepsis-induced NET formation depends on MYD88 but not GSDMD or PAD4, revealing distinct pathways for NET formation in different conditions.

This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.

The paper generates a tissue-specific cell type enrichment atlas using bulk RNAseq data from 15 human organs, identifying lowly expressed genes and shared gene signatures across cell types.