Manu Beerens

Prdm16 amplifies Notch signaling and suppresses venous lineage specification to prevent arteriovenous malformations during vascular development

This study shows Prdm16 enhances Notch signaling in arterial endothelial cells and suppresses venous fate to prevent arteriovenous malformations in zebrafish and human cells.

Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4

This study shows that sepsis-induced NET formation depends on MYD88 but not GSDMD or PAD4, revealing distinct pathways for NET formation in different conditions.

Cyclooxygenase-2 disruption predisposes to heart failure with preserved ejection fraction

This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.

Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes

The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.

RBPMS2 is a conserved regulator of alternative splicing that promotes myofibrillar organization and optimal calcium handling in cardiomyocytes

This study identifies RBPMS2 as a conserved regulator of alternative splicing that supports myofibril organization and calcium handling in cardiomyocytes across species.