Development of FAP-targeted theranostics discovered by next-generation sequencing-augmented mining of a novel immunized VNAR library
Gihan S. Gunaratne, Joseph P. Gallant, Kendahl L. Ott, Payson L. Broome, Sasha Celada, Jayden L. West, Jason C. Mixdorf, Eduardo Aluicio‐Sarduy, Jonathan W. Engle, Eszter Boros, Labros Meimetis, Joshua Michael Lang, Shuang George Zhao, Reinier T. Hernandez, David Kosoff, Aaron Matthew LeBeau
The paper develops FAP-targeted theranostics using VNARs from a shark antibody library, showing high affinity and efficacy in vitro and in vivo.
bioRxiv · Jan 13, 2025 · PreprintSynthetic Biology