Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids
Ioritz Sorzabal-Bellido, Xabier Morales, Iván Cortés‐Domínguez, Maider Esparza, Lara Grande, Pedro Castillo, Shruthi Narayanan, Mariano Ponz‐Sarvisé, Silvestre Vicent, Carlos Ortíz-de-Solórzano
This study evaluates how scaffold composition affects PDAC organoid phenotype, metabolism, and drug resistance, finding that collagen-Matrigel mixtures best mimic invasive tumors.
bioRxiv · Dec 31, 2024 · PreprintBioengineering