Author

Pei Min Lio

National Heart Centre Singapore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Anissa Anindya WidjajaiD· 2 shared Benjamin NgiD· 2 shared Brijesh Kumar SinghiD· 2 shared Eleonora AdamiiD· 2 shared Jessie Tan· 2 shared Jinrui DongiD· 2 shared Madhulika Tripathi· 2 shared Paul M. YeniD· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Anissa Anindya WidjajaORCID

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2 papers

Recent·Most cited

Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis

Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh Kumar Singh, Sonia Pankaj Chothani, Benjamin Ng, Wei‐Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini Guna Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, , Anissa Anindya Widjaja

The paper shows that autocrine IL11 signaling in hepatocytes drives lipotoxicity and NASH by causing lipoapoptosis and reactive oxygen species, with protection seen in Il11ra1-deleted mice.

Nature Communications · Jan 4, 2021Peer-reviewedMolecular Biology

IL-11 neutralising therapies target hepatic stellate cell-induced liver inflammation and fibrosis in NASH

Anissa Anindya Widjaja, Brijesh Kumar Singh, Eleonora Adami, Sivakumar Viswanathan, Jinrui Dong, Giuseppe Alessandro D’Agostino, Benjamin Ng, Wei‐Wen Lim, Jessie Tan, Bhairav Suryakant Paleja, Madhulika Tripathi, Sze Yun Lim, Shamini Guna Shekeran, Sonia Pankaj Chothani, Anne Rabes, , Stuart A. Cook

This study identifies IL-11 as a key driver of HSC-to-myofibroblast transformation in NASH, showing that targeting IL-11 reduces fibrosis and inflammation in preclinical models.

Gastroenterology · May 9, 2019Peer-reviewedMolecular Biology