Engineering Oncolytic Measles Virus with MG53 Couples Pyroptotic Tumor Killing with Immune Microenvironment Remodeling to Enhance Checkpoint Immunotherapy in Non-small Cell Lung Cancer
Zhongguang Li, Cheng Chih Hsu, Fei Jiang, Meng Bu, Umme Lubaba, S Li, Li Zhao, Peihui Lin, Hunter Piegols, Xuefeng Liu, Jiànróng Lǐ, Haichang Li
This paper engineers an oncolytic measles virus expressing MG53 to induce pyroptosis and immune remodeling, enhancing checkpoint immunotherapy in NSCLC.
bioRxiv · Jul 21, 2026 · PreprintImmunology