Author

Zhongguang Li

The Ohio State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Haichang LiiD· 3 shared Barbara BedogniiD· 1 shared Barbra S. MilleriD· 1 shared Caleb Araujo· 1 shared Changxian SheniD· 1 shared Cheng Chih HsuiD· 1 shared Daniel M. ChopykiD· 1 shared Fei JiangiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

Haichang LiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering Oncolytic Measles Virus with MG53 Couples Pyroptotic Tumor Killing with Immune Microenvironment Remodeling to Enhance Checkpoint Immunotherapy in Non-small Cell Lung Cancer

Zhongguang Li, Cheng Chih Hsu, Fei Jiang, Meng Bu, Umme Lubaba, S Li, Li Zhao, Peihui Lin, Hunter Piegols, Xuefeng Liu, Jiànróng Lǐ, Haichang Li

This paper engineers an oncolytic measles virus expressing MG53 to induce pyroptosis and immune remodeling, enhancing checkpoint immunotherapy in NSCLC.

bioRxiv · Jul 21, 2026 · PreprintImmunology

MG53 Protects Against Intestinal Inflammation by Inhibiting NLRP3 Inflammasome Activation

Zhongguang Li, Zachary D. Dawson, Xiangguang Li, Serenali Zhao, Mattew Bu, Fei Jiang, Yuchen Chen, M. Zhang, Xindi Zeng, Ki Ho Park, Jing Lu, Jinshan He, KyungEun Lee, Prosper N. Boyaka, Haichang Li, Jianjie Ma

This study shows that MG53 reduces intestinal inflammation by inhibiting NLRP3 inflammasome activation in colitis models.

Frontiers in Pharmacology · Mar 18, 2026Peer-reviewedImmunology

Targeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinoma

Changxian Shen, Liudmila V. Popova, Daniel M. Chopyk, Lindsey Hartshorn, Zhongguang Li, Yaoling Shu, Caleb Araujo, Shivam Priya, Varsha Thakur, John E. Phay, Barbra S. Miller, Barbara Bedogni, Haichang Li, Priya H. Dedhia

This study shows MMP-14 is critical for ACC cell survival and DNA repair, and its inhibition reduces viability and impairs repair mechanisms.

bioRxiv · Jan 7, 2026 · PreprintCancer Biology