An allosteric pocket in KV1.3 defines a distinct chemical space for immunomodulator design
Guoqing Luo, Xin Zhang, Huixin Xia, Ziyue Wei, Zheyang Zhang, Jia Sun, Zixuan Zhang, Yi Peng, Han Liu, Xuemeng Huang, Peng Cao, Mingqiang Rong, Ye Yu, Cheng Wu Tang
The paper identifies a novel allosteric pocket in KV1.3 that enables selective immunomodulator design, revealing a non-contact selectivity mechanism through structural analysis and inhibitor development.
bioRxiv · Jul 7, 2026 · PreprintBiochemistry