Chris Bowler

This paper develops a CRISPR-Cas9 method to generate lncRNA knockouts in the diatom Phaeodactylum tricornutum, demonstrating its utility in studying lncRNA function under phosphate stress.

PLMView is an unsupervised framework for fine-grained protein function classification from sequence, achieving high precision and speed without labeled data or model fine-tuning.

This study characterizes a novel microalgal protein xATPA, showing its environmental prevalence and functional role in plastidial physiology without ATP synthase activity.

The paper identifies a diverse microbial reservoir in the ultrasmall ocean fraction, including nitrogen-fixing diazotrophs, with implications for global biogeochemical cycles.

The paper characterizes the eukaryotic diversity in coral reef environments, revealing high diversity and identifying environmental drivers shaping these communities.

This study assesses the microbial biosynthetic potential of reef-building corals using genome-resolved metagenomics, revealing host-specific microbiomes with high biotechnological value.

This study investigates how transposable elements and gene family dynamics contribute to diatom diversification across different scales and evolutionary timescales.

This study examines how the polar diatom Fragilariopsis cylindrus adapts to extreme low light by revealing distinct physiological strategies and energy dissipation mechanisms.

This study generates absolute estimates of plankton cell concentrations and carbon biomass using environmental genomic data, revealing ecological associations and quantitative biogeographies of photosynthetic lineages.

This study identifies tryptophanol, a novel auxin analog in marine diatoms, which enhances nitrogen assimilation through a unique molecular mechanism.

The paper identifies a new MCF subfamily in diatoms, showing diverse localization and potential roles in nitrate assimilation.

This study analyzes diatom diversity and abundance in the global ocean using Tara Oceans data, identifying key environmental drivers and community patterns.

This study examines how the polar diatom Fragilariopsis cylindrus regulates its epigenome during the polar night, showing stable repression of transposable elements through H3K27me3 and DNA methylation.

DiatOmicBase integrates public diatom omics data to connect genes to functional processes, enabling exploratory analysis and experiment design.

QuartPlotR provides a visualization tool for multidimensional genomic datasets, enabling integration and analysis of sequence and annotation features across different genomic contexts.

The paper quantifies plankton community structure globally, revealing inverted biomass pyramids dominated by gelatinous organisms and predicting future shifts in oceanic carbon cycles.

The paper integrates a genome-scale model into an Earth System Model to study how environmental gradients affect metabolic processes in marine cyanobacteria.

The paper identifies and characterizes DNA methyltransferase diversity in marine microeukaryotes, showing that loss of DNMT5a leads to reduced DNA methylation and increased transposable element activity in diatoms.

The paper analyzes metatranscriptomes across a North Atlantic-Arctic gradient, finding differential and convergent gene expression changes in eukaryotic phytoplankton at the polar front.

The paper analyzes genetic divergence in three coral species across a Pacific environmental gradient, showing species-specific evolutionary patterns despite similar environments.

This study reports a chromosome-scale assembly of the allopolyploid diatom Fistulifera solaris genome using nanopore sequencing, revealing structural features and functional motifs.

This paper shows that H1 prevents H3K27me3 accumulation at telomeres and ITRs in Arabidopsis by restricting DNA accessibility to TRB proteins, while promoting PRC2 activity at genes.

The paper shows that mitotic interhomolog recombination generates genomic diversity in diatom clonal populations, with recombination rates exceeding 4% per cell division and increasing under stress.

The paper uses whole genome sequencing of ten Phaeodactylum tricornutum accessions to reveal genetic polymorphism, structure, and functional diversity across geographic and temporal scales.

The paper integrates transcriptome data to annotate the Phaeodactylum tricornutum genome, identifies novel genes and alternative splicing, and explores the evolutionary origins of diatoms.