Xin Zhang

The paper shows valine modulates mGluR5 in the prefrontal cortex to preserve social behavior through an allosteric mechanism.

The paper identifies a novel allosteric pocket in KV1.3 that enables selective immunomodulator design, revealing a non-contact selectivity mechanism through structural analysis and inhibitor development.

The paper reports the cryo-EM structure of the human P2X3 receptor complexed with sivopixant, revealing subtype-specific allosteric inhibition mechanisms and structural basis for improved selectivity.

APV-Sankey identifies high-affinity aptamers by visualizing K-mer evolution across SELEX rounds and filtering high-frequency sequences without affinity.