CDK11 activates CDK12 to trigger the elongation of RNA Polymerase II
Haolin Liu, Lingbo Li, Jun‐Feng Gao, Sonia M. Leach, Pengcheng Wei, Qianqian Zhang, Hua Huang, Thibault Houlès, Philippe P. Roux, Gongyi Zhang
This study identifies CDK11's role in phosphorylating hSpt5 and Rpb1, activating CDK12 to facilitate RNA Polymerase II elongation and shows CDK10 can partially compensate for CDK11.
bioRxiv · Sep 27, 2025 · PreprintBiochemistry