Philippe P. Roux

This study identifies IL-17RD as a negative regulator of RIG-I-like receptor-dependent antiviral immunity, showing it limits SARS-CoV-2-induced lung inflammation.

This study quantifies how RhoGTPase signalling controls cortical tension and cell shape using optogenetics and develops a predictive model linking signal gradients to mechanical changes.

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

This study identifies CDK11's role in phosphorylating hSpt5 and Rpb1, activating CDK12 to facilitate RNA Polymerase II elongation and shows CDK10 can partially compensate for CDK11.

The paper shows that increased PRMT5-MEP50 complex activity helps aneuploid cancer cells survive by reducing protein aggregation and proteotoxicity.

The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.

This study shows 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility in adipose precursor cells, impacting gene expression and fat mass.

This study identifies SR-4835 as a CDK12 inhibitor that promotes cyclin K degradation via the proteasome by recruiting the CDK12-cyclin K complex to the CUL4-RBX1-DDB1 ubiquitin ligase complex.

SPAT annotates proteins based on their likelihood to be at the cell surface using existing annotations, showing good performance on leukemia and public datasets.

The paper shows RSK phosphorylates RIOK2, promoting pre-40S particle maturation and ribosome synthesis in human cells.

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.