Sonia M. Leach

This study identifies MAIT cells as regulators of Treg responses in skin inflammation, showing their ability to resolve inflammation through IL-15-dependent mechanisms.

This study identifies that circulating and brain-resident memory CD8+ T cells contribute to distinct bystander TRM-like populations in glioblastoma, with brain TRM being a major source in GBM.

The paper identifies four types of fragile nucleosomes that facilitate RNA Polymerase II transcription in human cells by analyzing histone modifications and Pol II activity.

This study identifies CDK11's role in phosphorylating hSpt5 and Rpb1, activating CDK12 to facilitate RNA Polymerase II elongation and shows CDK10 can partially compensate for CDK11.

The paper identifies monocyte subsets associated with clinical outcomes in fibrotic hypersensitivity pneumonitis using single-cell RNA sequencing.

This study identifies distinct plasma proteomic signatures associated with different chest CT-defined phenotypes in sarcoidosis, linking them to specific molecular pathways and immune activity.

The paper introduces an ignorance-base, a knowledge base of known unknowns in prenatal nutrition literature, to identify new research avenues by analyzing ignorance statements and biomedical concepts.

This study shows GATA2 regulates mast cell identity and antigen responsiveness by enhancing chromatin accessibility at super-enhancers.

The paper introduces a method to identify and classify ignorance statements in biomedical text, creating a gold standard corpus and classifiers with high F1 scores.

This paper introduces a composite method for drug resistance prediction using mixed genomic data, showing improved performance on small sample sizes and mixed attribute types.

The paper examines immune cell changes in COPD patients and finds associations between cell counts and lung function decline, suggesting immune response roles in disease progression.