This study identifies CDK11's role in phosphorylating hSpt5 and Rpb1, activating CDK12 to facilitate RNA Polymerase II elongation and shows CDK10 can partially compensate for CDK11.

bioRxiv · Sep 27, 2025 · PreprintBiochemistry

The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

Thibault Houlès, Jonathan G. Boucher, Geneviève Lavoie, Graham Dickson and Hugh MacLeod, Sichun Lin, Stéphane Angers, Philippe P. Roux

This study identifies SR-4835 as a CDK12 inhibitor that promotes cyclin K degradation via the proteasome by recruiting the CDK12-cyclin K complex to the CUL4-RBX1-DDB1 ubiquitin ligase complex.

Cell Death Discovery · Dec 16, 2023Peer-reviewedMolecular Biology

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

Emilie L. Cerezo, Thibault Houlès, Oriane Lié, Marie-Kerguelen Sarthou, Charlotte Audoynaud, Geneviève Lavoie, Maral Halladjian, Sylvain Cantaloube, Carine Froment, Odile Burlet‐Schiltz, Yves A.L. Henry, Philippe P. Roux, Anthony K. Henras, Yves Roméo

The paper shows RSK phosphorylates RIOK2, promoting pre-40S particle maturation and ribosome synthesis in human cells.

PLoS Genetics · Jun 14, 2021Peer-reviewedMolecular Biology