Author

Haolin Liu

National Jewish HealthORCID 0009-0002-5583-2974Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:transcription & RNA processing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Gongyi ZhangiD· 4 shared Lingbo LiiD· 4 shared Qianqian ZhangiD· 4 shared Jun‐Feng GaoiD· 2 shared Sonia M. LeachiD· 2 shared Christopher J. OttiD· 1 shared Chuanyuan Li· 1 shared Ernesto Guccione· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersBiochemistry

Gongyi ZhangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enhancers Silence Coupled-coding RNAs in Animals

Gongyi Zhang, Lingbo Li, Song Mei, Haolin Liu, Xinjian Liu, Qianqian Zhang, Ernesto Guccione, Haitao Li, Chuanyuan Li

The paper identifies regulatory non-coding genes marked by nucleosome arginine methylation and regulated by JMJD5, showing their coupling with coding genes in animals.

bioRxiv · Nov 4, 2026 · PreprintBiochemistry

Enhancer/Enhanceosome/Super-enhancer and the promoter-proximate RNA Polymerase II (Pol II) pausing are coupled

Haolin Liu, Lingbo Li, Qianqian Zhang, Christopher J. Ott, Gongyi Zhang

The paper shows that BRD4 and p300/CBP regulate CDK9 activity, linking enhancer complex formation with promoter-proximal Pol II pausing.

bioRxiv · Dec 11, 2025 · PreprintBiochemistry

Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes

Lingbo Li, Samuel Hunter, Sonia M. Leach, Yonghua Zhuang, Haolin Liu, Jun‐Feng Gao, Qianqian Zhang, Timothy J. Stasevich, Hiroshi Kimurâ, Robin D. Dowell, Gongyi Zhang

The paper identifies four types of fragile nucleosomes that facilitate RNA Polymerase II transcription in human cells by analyzing histone modifications and Pol II activity.

bioRxiv · Oct 8, 2025 · PreprintGenetics

CDK11 activates CDK12 to trigger the elongation of RNA Polymerase II

Haolin Liu, Lingbo Li, Jun‐Feng Gao, Sonia M. Leach, Pengcheng Wei, Qianqian Zhang, Hua Huang, Thibault Houlès, Philippe P. Roux, Gongyi Zhang

This study identifies CDK11's role in phosphorylating hSpt5 and Rpb1, activating CDK12 to facilitate RNA Polymerase II elongation and shows CDK10 can partially compensate for CDK11.

bioRxiv · Sep 27, 2025 · PreprintBiochemistry