Structure-based discovery of new GPR119 ligands from on-demand tera-scale chemical space
M. V. T. Nguyen, Dongguyn Kim, Aleksey Raskovalov, Jayden Salve, Penghao Song, Anastasiia V Sadybekov, Olga O. Tarkhanova, Dmytro S Radchenko, Yurii S Moroz, Vadim Cherezov, Vsevolod Katritch
This study identifies new GPR119 agonists and antagonists by screening a tera-scale chemical space using structure-based methods and validates them with cryo-EM structures.
bioRxiv · Nov 10, 2026 · PreprintBiochemistry