Vadim Cherezov

This study identifies new GPR119 agonists and antagonists by screening a tera-scale chemical space using structure-based methods and validates them with cryo-EM structures.

The paper reports a cryo-EM structure of a 95-basepair DNA minicircle at 5.3 Å resolution, revealing its B-DNA configuration and structural features.

The paper presents cryo-EM structures of GPR119 bound to OEA and G proteins, revealing structural basis for G protein selectivity and lipid recognition.

This study solves cryo-EM structures of SpyCas9 bound to minicircle DNA, revealing how DNA shape affects Cas9 target interrogation and cleavage.

This study uses ABEL-FRET to measure structural dynamics of A2A adenosine receptors across timescales, showing agonists shift receptor states and accelerate conformational exchange.