Vsevolod Katritch

This study identifies new GPR119 agonists and antagonists by screening a tera-scale chemical space using structure-based methods and validates them with cryo-EM structures.

The paper adapts a general pharmacophore prescreening method to specific targets using fragment-docking data from the V-SYNTHES pipeline, improving its performance without additional data or retraining.

The paper presents cryo-EM structures of GPR119 bound to OEA and G proteins, revealing structural basis for G protein selectivity and lipid recognition.

This study identifies a potent cPLA2 inhibitor, BRI-50460, that modulates neuroinflammation and lipid homeostasis in Alzheimer's disease models.

The paper examines how sodium ions differentially modulate agonist-induced conformational changes and signaling at μ and κ opioid receptors, revealing opposing effects between the two receptor types.

This paper introduces a photoswitchable opioid agonist that enables optical control of peripheral analgesia with reduced side effects.

This study identifies angiotensin-(1-5) as a potent endogenous agonist of the AT2-receptor, showing its ability to increase nitric oxide release and lower blood pressure through AT2R-mediated mechanisms.