The common H202D variant in GDF-15 does not affect its bioactivity but can significantly interfere with measurement of its circulating levels
Yanislava Karusheva, Matthew Ratcliff, Alexander Mörseburg, Peter Barker, Audrey Melvin, Naveed A. Sattar, Keith Burling, Anna Backmark, Robert G. Roth, Lutz Jermutus, Esther Guiu‐Jurado, Matthias Blüher, Paul I. Welsh, Marko Hyvönen, Stephen O’Rahilly
The study shows that the H202D variant in GDF-15 does not affect its bioactivity but causes underreporting in R&D immunoassays, with correction equations provided.
The Journal of Applied Laboratory Medicine · Jul 7, 2022Peer-reviewedGenetic & Genomic Medicine