Matthias Blüher

This study identifies Slit3 fragments that coordinate neurovascular expansion and thermogenesis in brown adipose tissue by regulating angiogenesis and sympathetic innervation.

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

This study identifies sex-specific changes in the vascular niche of human adipose tissue in obesity, showing distinct structural and transcriptional differences between males and females.

This study identifies diet-temperature interactions that shape DNA methylation and gene regulation in brown adipose tissue, showing obesity limits cold-induced transcriptional responses.

This study identifies AZIN2 as a regulator of adipocyte progenitor fate through polyamine metabolism, showing its protective role against obesity and metabolic dysfunction.

This study evaluates the diagnostic yield of monogenic obesity in 521 patients using exome-wide data, finding 5.8% with monogenic obesity and 7.1% with potentially obesogenic variants.

The paper investigates how maternal thyroid hormone exposure affects DNA methylation at a leptin upstream enhancer in adipose tissue, with sex-specific impacts on body fat percentage.

The paper uses snRNA-seq to analyze human subcutaneous and visceral adipose tissue, identifying classical and specialized adipocyte subtypes and depot-specific patterns.

The paper identifies linoleic acid diols that inversely associate with BMI and activate adipocyte calcium fluxes using a novel tool called ScreenDMT.

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

The study shows that the H202D variant in GDF-15 does not affect its bioactivity but causes underreporting in R&D immunoassays, with correction equations provided.

The paper examines how lifestyle factors affect DNA methylation in blood, identifying DMPs and DMRs linked to lifestyle categories and biological pathways.

This study identifies AATBC as a human-specific lncRNA that regulates adipocyte plasticity and mitochondrial function, linking it to metabolic health.

This study identifies HAND2 as an obesity-linked adipogenic transcription factor regulated by glucocorticoids, showing its role in adipocyte differentiation and its correlation with BMI in humans.

This study identifies 15 common and 9 low-frequency protein-coding variants associated with body fat distribution, implicating novel genes related to lipid homeostasis and type 2 diabetes.