Author

Robert G. Roth

AstraZeneca (Sweden)ORCID 0000-0002-7084-6947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexander MörseburgiD· 1 shared Aman Mebrahtu· 1 shared Anna BackmarkiD· 1 shared Anna-Luisa VolkiD· 1 shared Audrey MelviniD· 1 shared Chih‐Chung Kuo· 1 shared David KotoliD· 1 shared Diane HattoniD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexander MörseburgORCID

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2 papers

Recent·Most cited

The common H202D variant in GDF-15 does not affect its bioactivity but can significantly interfere with measurement of its circulating levels

Yanislava Karusheva, Matthew Ratcliff, Alexander Mörseburg, Peter Barker, Audrey Melvin, Naveed A. Sattar, Keith Burling, Anna Backmark, Robert G. Roth, Lutz Jermutus, Esther Guiu‐Jurado, Matthias Blüher, Paul I. Welsh, Marko Hyvönen, Stephen O’Rahilly

The study shows that the H202D variant in GDF-15 does not affect its bioactivity but causes underreporting in R&D immunoassays, with correction equations provided.

The Journal of Applied Laboratory Medicine · Jul 7, 2022Peer-reviewedGenetic & Genomic Medicine

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins

Magdalena Malm, Chih‐Chung Kuo, Mona Moradi Barzadd, Aman Mebrahtu, Num Wistbacka, Ronia Razavi, Anna-Luisa Volk, Magnus Lundqvist, David Kotol, Hanna Tegel, Sophia Hober, Fredrik Edfors, Torbjörn Gräslund, Véronique Chotteau, Ray P. Field, , Johan Rockberg

The paper identifies secretory pathway differences between HEK293 and CHO cells that improve recombinant protein expression when switching hosts.

Metabolic Engineering · Mar 14, 2022Peer-reviewedSystems Biology