Soluble epoxide hydrolase upregulation in Alzheimer's disease promotes blood-brain barrier dysfunction
Murphy DeMeglio, Eloah S. De Biasi, Peter Breunig, Michael Candlish, Christina Sauerland, Stefan Günther, Haruya Kawase, Blanca Peguera, Christine Bohnstaedt, Peter R. Nilsson, Jiong Hu, Susanne S. Hille, Oliver J Mueller, Amparo Acker‐Palmer, Bruce D. Hammock, , Jasmin K. Hefendehl
This study shows that soluble epoxide hydrolase in astrocytes contributes to vascular instability in Alzheimer's disease, and its deletion reduces vascular amyloid burden and preserves vascular structure.
bioRxiv · Dec 11, 2025 · PreprintNeuroscience