Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian, Aliçia Stiévenard, Amit Khairnar, Felix Schmidt, Florian Giesert, Jochen Wolfgang Herms, Johannes Levin, Marianne Dieterich, Peter Falkai, Daniela M. Vogt Weisenhorn, Wolfgang Wurst, , Francisco J. Pan-Montojo
This study shows that extracellular alpha-synuclein toxicity in Parkinson's disease is independent of intracellular alpha-synuclein and linked to mitochondrial dysfunction.
Scientific Reports · Dec 19, 2022Peer-reviewedNeuroscience