Daniela M. Vogt Weisenhorn

PINK1 regulates cholesterol homeostasis via SCAP phosphorylation in human dopaminergic neurons

This study shows that PINK1 regulates cholesterol homeostasis in human dopaminergic neurons by phosphorylating SCAP, and restoring cholesterol levels rescues defects in neurotransmitter uptake.

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

This study shows that extracellular alpha-synuclein toxicity in Parkinson's disease is independent of intracellular alpha-synuclein and linked to mitochondrial dysfunction.

Canonical Wnt-signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons

This study shows that canonical Wnt/{beta}-catenin signaling modulates the timing and progression of dendritic growth in adult-born hippocampal neurons, with distinct effects in young and aged mice.

PINK1 Regulates Dopamine and Lipids at Mitochondria to Maintain Synapses and Neuronal Function

This study identifies PINK1's role in regulating mitochondrial function, lipid metabolism, and dopamine homeostasis in dopaminergic neurons, showing that cholesterol depletion can reverse PINK1-related phenotypes.