Peter Falkai

This study identifies shared genetic architecture between schizophrenia and substance use disorders using GWAS and genomic methods, finding significant genetic correlations and bidirectional causal relationships.

This study identifies BHLHE41 as a key regulator of lithium response in bipolar disorder by showing its role in neuronal excitability and synaptic plasticity through genetic and cellular analyses.

This study identifies 77 genetic loci associated with suicidality through genome-wide association analyses across multiple cohorts and provides biological insights into its genetic architecture.

The paper develops pathway-specific polygenic scores to predict lithium treatment response in bipolar disorder and finds associations with specific biological pathways.

This study examines the effects of theta-burst transcranial focused ultrasound on cerebral blood flow, functional connectivity, and metabolite levels in the primary motor cortex using multimodal neuroimaging.

This study identifies two clusters of severe mental disorder patients with differing illness severity, finding elevated pro-inflammatory serum proteins in the more severe group.

The paper evaluates how different functional connectivity metrics affect neuroimaging results and identifies metrics best suited for detecting age-related neural decline.

The paper identifies amacrine cells as enriched in schizophrenia genetic risk and links this to synaptic biology, while finding retinal immune cells associated with multiple sclerosis.

This study identifies alternative polyadenylation (APA) as a molecular mechanism linking polygenic risk for schizophrenia to synaptic impairments through functional analysis in induced neurons.

The paper identifies a novel miR-99b-5p-Zbp1 pathway in microglia that contributes to schizophrenia pathogenesis and suggests potential therapeutic strategies.

This study shows that extracellular alpha-synuclein toxicity in Parkinson's disease is independent of intracellular alpha-synuclein and linked to mitochondrial dysfunction.

This study shows that glycolic acid protects neurons from ischemic damage by reducing calcium-mediated excitotoxicity during reperfusion in stroke models.

The paper investigates genetic correlations between psychiatric disorders, personality traits, and SARS-CoV-2 susceptibility using GWAS data and individual-level polygenic risk scores.

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

The paper investigates how psychiatric disease and aging affect FKBP5 expression in the human brain, identifying supragranular neurons as key targets.

This study shows that DJ-1 metabolites GA and DL can rescue fertility and mitochondrial dysfunction in multiple species, with GA having broader effects across models.

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.