Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models
Dimitra Sokolova, Shari Addington Ghansah, Francesca Puletti, Tatiana Georgiades, Sebastiaan De Schepper, Yongjing Zheng, Gerard Crowley, Ling Wu, Javier Rueda‐Carrasco, Angeliki Koutsiouroumpa, Philip Muckett, Oliver J. Freeman, Baljit S. Khakh, Soyon Youngae Hong
This study identifies astrocyte-derived MFG-E8 as a key mediator of microglial synapse elimination in Alzheimer's disease mouse models, showing its role in synapse loss and potential as a therapeutic target.
bioRxiv · Aug 31, 2024 · PreprintNeuroscience