Javier Rueda‐Carrasco

This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.

This paper presents a short-term performance assay in mice to evaluate functional benefits and early toxicity of anti-aging interventions, identifying compound-specific effects and highlighting potential toxicity.

This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.

This study identifies astrocyte-derived MFG-E8 as a key mediator of microglial synapse elimination in Alzheimer's disease mouse models, showing its role in synapse loss and potential as a therapeutic target.

Microglia selectively engulf synapses in Alzheimer-like mouse brains via PtdSer-TREM2 signaling.

This study shows that SFRP1 from astrocytes promotes microglial activation in acute and chronic neuroinflammation, suggesting it as a therapeutic target.

This study shows that Sfrp1 deficiency leads to photoreceptor degeneration and increased light-induced damage in mice, highlighting SFRP1's role in maintaining outer limiting membrane integrity.