Tau depletion in human neurons mitigates A beta-driven toxicity
Bryan Ng, Jane Vowles, Féodora L. Bertherat, Ajantha S Abey, Peter Kilfeather, Dayne A. Beccano-Kelly, M. Irina Stefana, Darragh Patrick O'Brien, Nora Bengoa‐Vergniory, Phillippa J. Carling, John A. Todd, Tara M. Caffrey, Natalie Connor‐Robson, Sally A. Cowley, Richard Wade‐Martins
This study shows that reducing tau in human neurons decreases A beta toxicity, supporting the role of tau in Alzheimer's disease mechanisms.
Molecular Psychiatry · Feb 15, 2024Peer-reviewedNeuroscience